Signal65’s Ryan Shrout and Russ Fellows discuss HPE’s unified ProLiant compute stack with Ganesh Subramanian, exploring cloud-native fleet management, AI-assisted operations, edge resilience, and how policy-driven orchestration is redefining enterprise infrastructure.

Arm moves closer to owning the silicon layer, OpenAI sharpens its enterprise strategy, and a wave of geopolitical and market pressures exposes what is really driving the AI race. Patrick Moorhead and Daniel Newman unpack how compute constraints, capital intensity, and supply chain risk are starting to dictate who can scale, who can compete, and who gets left behind as the industry shifts from experimentation to execution.

AI is turning data into the most valuable asset in the enterprise, but only if it can be secured, understood, and delivered at speed. Everpure explains why data infrastructure is evolving beyond storage into intelligence platforms built for AI.

Host Diana Blass and Six Five Media bring together Dell leaders to explore how enterprise PCs and workstations are evolving for the AI era with AI workloads, engineering innovations, and premium user experiences, reshaping the future of enterprise computing.

Ryan Shrout speaks with Dell Technologies leaders Rob Bruckner, Charlie Walker, and Paul Doczy about how the new Dell Pro Precision portfolio is enabling AI development, advanced engineering workflows, and high-performance creation with scalable workstation platforms.

Rob Bruckner, Zach Noskey, and Paul Doczy join Olivier Blanchard to discuss Dell’s reinvention of the commercial PC portfolio, including accelerated roadmaps, modular architecture, and the engineering innovations behind the new Dell Pro lineup.

Jeff Clarke and Rob Bruckner join Patrick Moorhead and Daniel Newman to discuss Dell’s commercial PC strategy, the role of engineering excellence in the Dell Pro lineup, and how AI-enabled devices are reshaping enterprise computing.

Roman Chernin joins Patrick Moorhead and Daniel Newman to discuss how AI infrastructure is shifting from training to inference, why Nebius built Token Factory to optimize system-level performance, and how agent-driven ROI will define AI success in 2026 and beyond.

Tom Cosenza joins Daniel Newman and Greg Lotko to discuss how quantum computing is reshaping enterprise security strategy, the risks of delaying post-quantum preparation, and why building a cryptographic inventory is the first critical step toward resilience.

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AI is accelerating breakthroughs in fusion energy and materials science, but infrastructure remains the limiting factor. Lenovo and Quantum Formatics explore how private AI environments and purpose-built systems are enabling the next wave of discovery.

AI is becoming a scale and control business. On Episode 297 of The Six Five Pod, Patrick Moorhead and Daniel Newman examine the companies building the infrastructure, forming the alliances, and making the moves that will define who wins and who gets squeezed out. Control is shifting across compute, models, infrastructure, and enterprise distribution as NVIDIA, Microsoft, OpenAI, Meta, and others push to control the next phase of the AI market.

AI is moving fast, but most organizations are not ready for what it takes to deploy it at scale. HPE’s Trish Damkroger explains why infrastructure, not models, is now the limiting factor and how the “AI factory” is redefining enterprise execution.